Research

Real-Time Visualization of RNA Dynamics in Living Systems

We develop and apply novel imaging technologies to visualize RNA regulation in living tissues at the single-cell, single-molecule level. By visualizing endogenous RNA expression dynamics in real time, we aim to understand how neural activity modulates transcription, ultimately influencing circuit connectivity and behavior.

Molecular Mechanisms of mRNA Transport and Localization

Our lab investigates the molecular mechanisms of mRNA transport and localization in live cells. Specifically, we focus on uncovering the unique dynamics of single mRNA transport in dendrites and axons of hippocampal neurons. Through a combination of single-molecule RNA imaging and theoretical modeling, we aim to achieve a quantitative understanding of the complex regulatory processes governing mRNA localization and its role in neural function. 

Blood-Based Biomarkers for Early Detection of Neurodegenerative Diseases

We are developing non-invasive, blood-based biomarkers to detect early molecular signatures of neurodegenerative diseases. By integrating seed amplification assay (SAA) and novel biosensing technologies, we seek to bridge fundamental neuroscience with translational applications for early diagnosis and intervention.