Publications

 

  2023

  • Ahn, H., Durang, X., Shim, J. Y., Park, G., Jeon, J. H., & Park, H. Y. (2023). Statistical modeling of mRNP transport in dendrites: A comparative analysis of β‐actin and Arc mRNP dynamics. Traffic, 24(11), 522-532. https://doi.org/10.1111/tra.12913 
  • Noh, K., Cho, W. H., Lee, B. H., Kim, D. W., Kim, Y. S., Park, K., ... & Lee, S. J. (2023). Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance. Nature neuroscience, 26(9), 1541-1554. https://doi.org/10.1038/s41593-023-01406-4 
  • Cho, W. H., Noh, K., Lee, B. H., Barcelon, E., Jun, S. B., Park, H. Y., & Lee, S. J. (2022). Hippocampal astrocytes modulate anxiety-like behavior. Nature communications, 13(1), 6536. https://doi.org/10.1038/s41467-022-34201-z 
  • Lee, C., Lee, B. H., Jung, H., Lee, C., Sung, Y., Kim, H., ... & Kaang, B. K. (2023). Hippocampal engram networks for fear memory recruit new synapses and modify pre-existing synapses in vivo. Current Biology. https://doi.org/10.1016/j.cub.2022.12.038
  • Durang, X., Ahn, H., Shim, J. Y., Park, H. Y., & Jeon, J. H. (2023). Accessing power-law statistics under experimental constraints. Physical Review Research, 5(1), 013011. https://doi.org/10.1103/PhysRevResearch.5.013011

 

  2022

  • Cho, W. H., Noh, K., Lee, B. H., Barcelon, E., Jun, S. B., Park, H. Y., & Lee, S. J. (2022). Hippocampal astrocytes modulate anxiety-like behavior. Nature Communications, 13(1), 1-14. https://doi.org/10.1038/s41467-022-34201-z
  • Lee, Byung Hun, Seokyoung Bang, Seung‐Ryeol Lee, Noo Li Jeon, and Hye Yoon Park.  "Dynamics of axonal β‐actin mRNA in live hippocampal neurons." Traffic (2022). https://doi.org/10.1111/tra.12865
  • Lee, Byung Hun, Jae Youn Shim, Hyungseok C. Moon, Dong Wook Kim, Jiwon Kim, Jang Soo Yook, Jinhyun Kim, and Hye Yoon Park. "Real-time visualization of mRNA synthesis during memory formation in live mice." Proceedings of the National Academy of Sciences 119, no. 27 (2022): e2117076119.  https://doi.org/10.1073/pnas.2117076119
  • Choi, H., Lee, B. H., & Park, H. Y. (2022). Time-resolved analysis of transcription kinetics in single live mammalian cells. Frontiers in Physics, 1094. https://doi.org/10.3389/fphy.2022.977125
  • Kim, Yumin, Kang, Sangyoon, Lee, Byung Hun, Song, Youngjun, Kang, Sunah, Park, Hye Yoon, and Lee, Yan. “De Novo Generation of a Bright Blue Fluorophore from 2-Oxoglutarate in Biological Samples.” Chemical Science. 13, no. 2 (2022): 365–72. https://doi.org/10.1039/D1SC05808H

 

  2021

  • Hong, Yujin, Heena Jeong, Kiwon Park, Sungwon Lee, Jae Youn Shim, Hyewon Kim, Yang Song et al. "STING facilitates nuclear import of herpesvirus genome during infection." Proceedings of the National Academy of Sciences 118, no. 33 (2021): e2108631118. https://doi.org/10.1073/pnas.2108631118
  • Park, Kiwon, Jeongmin Ryoo, Heena Jeong, Minsu Kim, Sungwon Lee, Sung-Yeon Hwang, Jiyoung Ahn et al. "Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions." PLoS genetics 17, no. 4 (2021): e1009523. https://doi.org/10.1371/journal.pgen.1009523
  • Song, Minho S., Hyeonjun Baek, Keundong Lee, Dongha Yoo, Kunook Chung, Jamin Lee, Hyungseok C. Moon, Byung Hun Lee, Hye Yoon Park, and Gyu-Chul Yi. "Intracellular gallium nitride microrod laser." NPG Asia Materials 13, no. 1 (2021): 1-6. https://doi.org/10.1038/s41427-021-00299-8
  • Choi, Hongyoung, Byung Hun Lee, and Hye Yoon Park. "Quantitative models for transcriptional dynamics monitored using an MS2-GFP system." Journal of the Korean Physical Society 78, no. 5 (2021): 365-372. https://doi.org/10.1007/s40042-020-00037-3
  • Hwang, Sung-Yeon, Hyunchul Jung, Seyoung Mun, Sungwon Lee, Kiwon Park, S. Chan Baek, Hyungseok C. Moon et al. "L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force." Nature communications 12, no. 1 (2021): 1-14. https://doi.org/10.1038/s41467-021-21197-1

 

  2020

  • Moon, Hyungseok C., Sulagna Das, Robert H. Singer, and Hye Yoon Park. "Real-Time Imaging of Transcription and Transport of Single Arc mRNA in Live Neurons." Biophysical Journal 118, no. 3 (2020): 545a. https://doi.org/10.1016/j.bpj.2019.11.2982
  • Park, Sung Young, Hyungseok C. Moon, and Hye Yoon Park. "Live-cell imaging of single mRNA dynamics using split superfolder green fluorescent proteins with minimal background." RNA 26, no. 1 (2020): 101-109. https://doi.org/10.1261/rna.067835.118

 

  2019

  • Kim, Songhee H., Melissa Vieira, Jae Youn Shim, Hongyoung Choi, and Hye Yoon Park. "Recent progress in single-molecule studies of mRNA localization in vivo." RNA biology 16, no. 9 (2019): 1108-1118. https://doi.org/10.1080/15476286.2018.1536592
  • Shim, Jae Youn, Byun Hun Lee, Hyung Seok Moon, and Hye Yoon Park. "The role of beta-actin mRNA localization in single dendritic spines studied by two-photon uncaging." IBRO Reports 6 (2019): S273. https://doi.org/10.1016/j.ibror.2019.07.847
  • Stueland, Michael, Tianhong Wang, Hye Yoon Park, and Stavroula Mili. "RDI calculator: an analysis tool to assess RNA distributions in cells." Scientific reports 9, no. 1 (2019): 1-10. 
    https://doi.org/10.1038/s41598-019-44783-2
  • Kim, Songhee H., Melissa Vieira, Hye-Jin Kim, Mahipal Singh Kesawat, and Hye Yoon Park. "MS2 labeling of endogenous beta-actin mRNA does not result in stabilization of degradation intermediates." Molecules and cells 42, no. 4 (2019): 356. https://doi.org/10.14348/molcells.2019.2398
  • Choi, Yoori, Dohyun Kim, Hye Yoon Park, Kyu Wan Kim, Mee Young Kim, Chul-Kee Park, and Dong Soo Lee. "Graphene oxide-quenching-based fluorescence in situ hybridization (G-FISH) to detect RNA in tissue: Simple and fast tissue RNA diagnostics." Nanomedicine: Nanotechnology, Biology and Medicine 16 (2019): 162-172. https://doi.org/10.1016/j.nano.2018.12.004
  • Shim, Jae Youn, Byung Hun Lee, and Hye Yoon Park. "Visualization of Single mRNAs in Live Neurons." In Imaging Gene Expression, pp. 47-61. Humana, New York, NY, 2019. https://doi.org/10.1007/978-1-4939-9674-2_4

 

  2018

  • Das, Sulagna, Hyungseok C. Moon, Robert H. Singer, and Hye Yoon Park. "A transgenic mouse for imaging activity-dependent dynamics of endogenous Arc mRNA in live neurons." Science advances 4, no. 6 (2018): eaar3448. https://doi.org/10.1126/sciadv.aar3448
  • Song, Minho S., Hyungseok C. Moon, Jae-Hyung Jeon, and Hye Yoon Park. "Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk." Nature communications 9, no. 1 (2018): 1-8. https://doi.org/10.1038/s41467-017-02700-z
  • Lee, Byung Hun, and Hye Yoon Park. "HybTrack: A hybrid single particle tracking software using manual and automatic detection of dim signals." Scientific reports 8, no. 1 (2018): 1-7. https://doi.org/10.1038/s41598-017-18569-3

 

  2017

  • Baek, Hyeonjun, Hankyul Kwak, Minho S. Song, Go Eun Ha, Jongwoo Park, Youngbin Tchoe, Jerome K. Hyun, Hye Yoon Park, Eunji Cheong, and Gyu-Chul Yi. "ZnO nanotube waveguide arrays on graphene films for local optical excitation on biological cells." APL Materials 5, no. 4 (2017): 046106. https://doi.org/10.1063/1.4981646

 

  2016

  • Lee, Byung Hun, Seong-Woo Bae, Jaeyoun Jay Shim, Sung Young Park, and Hye Yoon Park. "Imaging single-mRNA localization and translation in live neurons." Molecules and cells 39, no. 12 (2016): 841. https://doi.org/10.14348/molcells.2016.0277
  • Vera, Maria, Jeetayu Biswas, Adrien Senecal, Robert H. Singer, and Hye Yoon Park. "Single-cell and single-molecule analysis of gene expression regulation." Annual review of genetics 50 (2016): 267. https://doi.org/10.1146/annurev-genet-120215-034854
  • Moon, Hyungseok C., Byung Hun Lee, Kiseong Lim, Jae Seok Son, Minho S. Song, and Hye Yoon Park. "Tracking single mRNA molecules in live cells." Journal of Physics D: Applied Physics 49, no. 23 (2016): 233001. https://doi.org/10.1016/S0076-6879(10)72003-6
  • Moon, H. C., and H. Y. Park. "Imaging single mRNA dynamics in live neurons and brains." In Methods in enzymology, vol. 572, pp. 51-64. Academic Press, 2016. https://doi.org/10.1016/bs.mie.2016.02.015
  • Park, Hye Yoon, and Minho Song. "Visualizing mRNA Dynamics in Live Neurons and Brain Tissues." In Post-Transcriptional Gene Regulation, pp. 325-334. Humana Press, New York, NY, 2016. https://doi.org/10.1007/978-1-4939-3067-8_21

 

  2015

  • Monnier, Nilah, Zachary Barry, Hye Yoon Park, Kuan-Chung Su, Zachary Katz, Brian P. English, Arkajit Dey et al. "Inferring transient particle transport dynamics in live cells." Nature methods 12, no. 9 (2015): 838-840. https://doi.org/10.1038/nmeth.3483
  • Buxbaum, Adina R., Young J. Yoon, Robert H. Singer, and Hye Yoon Park. "Single-molecule insights into mRNA dynamics in neurons." Trends in cell biology 25, no. 8 (2015): 468-475. https://doi.org/10.1016/j.tcb.2015.05.005
  • Barry, Zachary, Nilah Monnier, Hye Yoon Park, Kuan-Chung Su, Zachary Katz, Brian P. English, Arkajit Dey et al. "Bayesian Classification of Mrna and Kinetochore Transport Dynamics." Biophysical Journal 108, no. 2 (2015): 164a-165a. https://doi.org/10.1016/j.bpj.2014.11.907

 

  2014

  • Park, Hye Yoon, Hyungsik Lim, Young J. Yoon, Antonia Follenzi, Chiso Nwokafor, Melissa Lopez-Jones, Xiuhua Meng, and Robert H. Singer. "Visualization of dynamics of single endogenous mRNA labeled in live mouse." Science 343, no. 6169 (2014): 422-424. https://doi.org/10.1126/science.1239200

 

  2012

  • Katz, Zachary B., Amber L. Wells, Hye Yoon Park, Bin Wu, Shailesh M. Shenoy, and Robert H. Singer. "β-Actin mRNA compartmentalization enhances focal adhesion stability and directs cell migration." Genes & development 26, no. 17 (2012): 1885-1890. https://doi.org/10.1101/gad.190413.112
  • Park, Hye Yoon, Tatjana Trcek, Amber L. Wells, Jeffrey A. Chao, and Robert H. Singer. "An unbiased analysis method to quantify mRNA localization reveals its correlation with cell motility." Cell reports 1, no. 2 (2012): 179-184. https://doi.org/10.1016/j.celrep.2011.12.009
  • Trcek, Tatjana, Jeffrey A. Chao, Daniel R. Larson, Hye Yoon Park, Daniel Zenklusen, Shailesh M. Shenoy, and Robert H. Singer. "Single-mRNA counting using fluorescent in situ hybridization in budding yeast." Nature protocols 7, no. 2 (2012): 408-419. https://doi.org/10.1038/nprot.2011.451
  • Park, Hye Yoon, Young Yoon, Chiso Nwokafor, Melissa Lopez-Jones, Xiuhua Meng, Antonia Follenzi, Hyungsik Lim, and Robert H. Singer. "A Transgenic Mouse Model for Imaging Single RNA Dynamics In Vivo." Biophysical Journal 102, no. 3 (2012): 600a. https://doi.org/10.1016/j.bpj.2011.11.3267
  • Singer, Robert H., Timothee Lionnet, Hye Yoon Park, Bin Wu, Tatjana Trcek, Sami Hocine, and Daniel Larson. "Following Single mRNAs from Birth to Death in Living Cells." Biophysical Journal 102, no. 3 (2012): 609a-610a. https://doi.org/10.1016/j.bpj.2011.11.3323
  • Gu, Wei, Zachary Katz, Bin Wu, Hye Yoon Park, Deling Li, Stanley Lin, Amber L. Wells, and Robert H. Singer. "Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1." Journal of cell science 125, no. 1 (2012): 81-91. https://doi.org/10.1242/jcs.086132

 

  2011

  • Lionnet, Timothée, Kevin Czaplinski, Xavier Darzacq, Yaron Shav-Tal, Amber L. Wells, Jeffrey A. Chao, Hye Yoon Park, Valeria De Turris, Melissa Lopez-Jones, and Robert H. Singer. "A transgenic mouse for in vivo detection of endogenous labeled mRNA." Nature methods 8, no. 2 (2011): 165-170. https://doi.org/10.1038/nmeth.1551
  • Katz, Z. B., A. L. Wells, B. Wu, H. Y. Park, S. M. Shenoy, and R. H. Singer. "beta-actin mRNA compartmentalization by ZBP1 controls focal adhesion stability and directed cell motility." In MOLECULAR BIOLOGY OF THE CELL, vol. 22. 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY, 2011. 

 

  2010

 

  2009

  • Kim, Chul, Sung Hwan Jeong, Jae Jeong Shim, Seung-Ick Cha, Choonhee Son, Man Pyo Chung, Hye Yoon Park et al. "Clinical features of pulmonary langerhans cell histiocytosis in Korea." Tuberculosis and Respiratory Diseases 66, no. 2 (2009): 98-103. https://doi.org/10.4046/trd.2009.66.2.98
  • Li, Li, Suzette A. Pabit, Jessica S. Lamb, Hye Yoon Park, and Lois Pollack. "Closing the lid on DNA end-to-end stacking interactions." Applied physics letters 92, no. 22 (2008): 223901. https://doi.org/10.1016/j.bpj.2008.12.1739

 

  2008

  • Lamb, Jessica, Lisa Kwok, Xiangyun Qiu, Kurt Andresen, Hye Yoon Park, and Lois Pollack. "Reconstructing three-dimensional shape envelopes from time-resolved small-angle X-ray scattering data." Journal of applied crystallography 41, no. 6 (2008): 1046-1052. https://doi.org/10.1107/S0021889808028264
  • Andresen, Kurt, Xiangyun Qiu, Suzette A. Pabit, Jessica S. Lamb, Hye Yoon Park, Lisa W. Kwok, and Lois Pollack. "Mono-and trivalent ions around DNA: a small-angle scattering study of competition and interactions." Biophysical journal 95, no. 1 (2008): 287-295. https://doi.org/10.1529/biophysj.107.123174
  •  Schlatterer, Jörg C., Lisa W. Kwok, Jessica S. Lamb, Hye Yoon Park, Kurt Andresen, Michael Brenowitz, and Lois Pollack. "Hinge stiffness is a barrier to RNA folding." Journal of molecular biology 379, no. 4 (2008): 859-870. https://doi.org/10.1016/j.jmb.2008.04.013
  • Li, Li, Suzette A. Pabit, Jessica S. Lamb, Hye Yoon Park, and Lois Pollack. "Closing the lid on DNA end-to-end stacking interactions." Applied physics letters 92, no. 22 (2008): 223901. https://doi.org/10.1063/1.2937402​​​​​​​
  • Park, Hye Yoon, Sally A. Kim, Jonas Korlach, Elizabeth Rhoades, Lisa W. Kwok, Warren R. Zipfel, M. Neal Waxham, Watt W. Webb, and Lois Pollack. "Conformational changes of calmodulin upon Ca2+ binding studied with a microfluidic mixer." Proceedings of the National Academy of Sciences 105, no. 2 (2008): 542-547. https://doi.org/10.1073/pnas.0710810105
  • Qiu, Xiangyun, Suzette A. Pabit, Jessica S. Lamb, and Hye Yoon Park. "Mono-and Trivalent Ions around DNA: A Small-Angle Scattering Study of Competition and Interactions." molecules 12 (2008): 15. https://doi.org/10.1529/biophysj.107.123174·Source

 

  2007

  • Qiu, Xiangyun, Kurt Andresen, Lisa W. Kwok, Jessica S. Lamb, Hye Yoon Park, and Lois Pollack. "Inter-DNA attraction mediated by divalent counterions." Physical review letters 99, no. 3 (2007): 038104. https://doi.org/10.1103/PhysRevLett.99.038104
  • Andresen, Kurt, Jessica Lamb, Xiangyun Qiu, Lisa Kwok, Hye Yoon Park, and Lois Pollack. "Anomalous small-angle x-ray scattering (ASAXS) study of multivalent ion-DNA interactions." In APS March Meeting Abstracts, pp. V35-008. 2007. 
  • Lamb, Jessica S., Sterling Cornaby, Kurt Andresen, Lisa Kwok, Hye Yoon Park, Xiangyun Qiu, D-M. Smilgies, Donald H. Bilderback, and Lois Pollack. "Focusing capillary optics for use in solution small-angle X-ray scattering." Journal of Applied Crystallography 40, no. 1 (2007): 193-195. https://doi.org/10.1107/S0021889806044505

 

  2006

  • Turner, Stephen, Jun Kameoka, Hye Park, and Harold Craighead. "Three dimensional microfluidic device having porous membrane." U.S. Patent Application 10/372,016, filed September 25, 2003.
  • Park, Hye Yoon, Xiangyun Qiu, Elizabeth Rhoades, Jonas Korlach, Lisa W. Kwok, Warren R. Zipfel, Watt W. Webb, and Lois Pollack. "Achieving uniform mixing in a microfluidic device: hydrodynamic focusing prior to mixing." Analytical chemistry 78, no. 13 (2006): 4465-4473. https://doi.org/10.1021/ac060572n
  • Qiu, Xiangyun, Lisa W. Kwok, Hye Yoon Park, Jessica S. Lamb, Kurt Andresen, and Lois Pollack. "Measuring inter-DNA potentials in solution." Physical review letters 96, no. 13 (2006): 138101. https://doi.org/10.1103/PhysRevLett.96.138101
  • Andresen, Kurt, Lisa Kwok, Xiangyun Qiu, Hye Yoon Park, Jessica Lamb, and Lois Pollack. "Ion Distribution around DNA: Can Transitions Be Observed?." In APS March Meeting Abstracts, pp. R26-011. 2006. 
  • Kwok, Lisa W., Inna Shcherbakova, Jessica S. Lamb, Hye Yoon Park, Kurt Andresen, Heather Smith, Michael Brenowitz, and Lois Pollack. "Concordant exploration of the kinetics of RNA folding from global and local perspectives." Journal of molecular biology 355, no. 2 (2006): 282-293. https://doi.org/10.1016/j.jmb.2005.10.070

 

  2005

  • Andresen, Kurt, Rhiju Das, Hye Yoon Park, Heather Smith, Lisa Kwok, Daniel J. Herschlag, Kenneth D. Finkelstein, and Lois Pollack. "Competition and spatial distribution of ions diffusively bound to DNA." In APS March Meeting Abstracts, pp. X21-009. 2005. 

 

  2004

  • Andresen, Kurt, R. Das, Hye Yoon Park, H. Smith, Lisa W. Kwok, Jessica S. Lamb, E. J. Kirkland, D. Herschlag, K. D. Finkelstein, and Lois Pollack. "Spatial distribution of competing ions around DNA in solution." Physical review letters 93, no. 24 (2004): 248103. https://doi.org/10.1103/PhysRevLett.93.248103

 

  2003

  • Turner, Stephen, Jun Kameoka, Hye Park, and Harold Craighead. "Three dimensional microfluidic device having porous membrane." U.S. Patent Application 10/372,016, filed September 25, 2003.